Clinical Significance of MMP-7 and PTEN Expression in Colorectal ...

Zheng Bi, Lai-Dong Dong and Xiao-Meng Gu

DOI 10.5754/hge12537

2013; 60(121): Ahead of print.

KEY WORDS: Colorectal cancer; MMP-7; PTEN; Immunohistochemistry; Clinicopathological parameter.

ABSTRACT

Background/Aims: The aim of this study was to investigate the expression of MMP-7 and PTEN protein in colorectal cancer and explore its correlation with clinicopathological parameters. Methodology: In colorectal cancer tissue samples (n=48) and normal rectal tissue samples (n=23), the expression of MMP-7 and PTEN was detected by immunohistochemistry. Using medical records, the relationship of MMP-7 and PTEN expression with clinicopathological parameters was analyzed. Results: Compared to normal rectal tissue, MMP-7 expression was significantly higher in all grades of colorectal cancer. In contrast, PTEN expression was significantly lower than levels in normal rectal tissue. There was significant negative correlation between MMP-7 and PTEN expression in colorectal cancer (r=-0.403, p>0.05). MMP-7 and PTEN expression in colorectal cancer samples was correlated with differentiation, lymph node metastasis, serosa infiltration, and Duke?s stage (p<0.05) but not with gender, age, or tumor size (p>0.05). Conclusions: Reduced PTEN expression and MMP-7 over-expression may play important roles in the pathogenesis of colorectal cancer. Combined detection may provide prognostic benefit towards colorectal cancer.

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Source: https://www.hepato-gastroenterology.org/?p=5695

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